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Asahara Lab
Systems BioMedicine
Mitsumura T#, Ito Y#, Chiba T#, Matsushima T, Kurimoto R, Tanaka Y, Kato T, Uchida K, Ito T, Yamamoto K, Eishi Y, Kitagawa M, Miyazaki Y, Inase N, Asahara H*. Ablation of miR-146b in mice causes hematopoietic malignancy. Blood Adv. 2018 Dec 11;2(23):3483-3491.
Mochizuki Y, Chiba T, Kataoka K, Yamashita S, Sato T, Kato T, Takahashi K, Miyamoto T, Kitazawa M, Hatta T, Natsume T, Takai S, Asahara H*. Combinatorial CRISPR/Cas9-approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression. Dev Cell. 2018 Sep 24;46(6):794-806.
Inui M*, Mokuda S, Sato T, Tamano M, Takada S, Asahara H*. Dissecting the roles of miR-140 and its host gene. Nat Cell Biol. 2018 May;20(5):516-518.
Ito Y, Inoue A, Seers T, Hato Y, Igarashi A, Toyama T, Taganov K, Boldin M, Asahara H*. Identification of targets of tumor suppressor microRNA-34a using a reporter library system. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3927-3932.
Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H*. Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction. PLoS Genetics. 2017 Jan 23;13(1):e1006578.
Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H*. Mohawk transcription factor regulates homeostasis of the periodontal ligament. Development. 2017 Jan 15;144(2):313-320.
Naito M, Mori M, Inagawa M, Miyata K, Hashimoto N, Tanaka S, Asahara H*. Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2. PLoS Genetics. 2016 Jul 14;12(7):e1006167.
Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz M, Sakai D, Masuda K, Ozaki T, Asahara H*. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016 Aug 16;7:12503.
Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz M, Okawa A, Asahara H*. Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5.
Uchida Y, Kurimoto R, ChibaT, Matsushima T, Oda G, Onishi I, Takeuchi Y, Gotoh N, Asahara H*. RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer. EMBO Rep. in press.
Yagasaki L, Chiba T, Kurimoto R, Nakajima M, Iwata T, Asahara H*. The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther. 2023 Dec 29;25:186-193.
Inotsume M#, Chiba T#, Matsushima T, Kurimoto R, Nakajima M, Kato T, Shishido K, Liu L, Kawakami K, Asahara H*. One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023 Apr;597(7):975-984. Epub 2023 Mar 20.(+VIDEO)
Yamamoto H#, Uchida Y#, Kurimoto R#, Chiba T, Matsushima T, Ito Y, Inotsume M, Miyata K, Watanabe K, Inada M, Goshima N, Uchida T, Asahara H*. LIN28A upregulates HIF1α by post-transcriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023 Jan;299(1):102791.
Nakamichi R, Ma S, Nonoyama T, Chiba T, Kurimoto R, Ohzono H, Olmer M, Shukunami C, Fuku N, Wang F, Morrison E, Pitsiladis YP, Ozaki T, D’Lima D, Lotz M, Patapoutian A, Asahara H*. The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Sci Transl Med. 2022 Jun;14(647):eabj5557.
Ito Y, Matsuzaki T, Ayabe F, Mokuda S, Kurimoto R, Matsushima T, Mochizuki Y, Inotsume M, Tsutsumi H, Liu L, Shinohara M, Tanaka Y, Nakamichi R, Nishida K, Lotz M, Asahara H*. Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis. Nat Commun. 2021 Jul 6;12(1):4148 .
Kurimoto R, Chiba T, Ito Y, Matsushima T, Yano Y, Miyata K, Yashiro Y, Suzuki T, Tomita K, Asahara H*. The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA. EMBO J. 2020 e104708.
Sato T, Kataoka K, Ito Y, Yokoyama S, Inui M, Mori M, Takahashi S, Akita K, Takada S, Ueno-Kudoh H, Asahara H*. Lin28a/let-7 Pathway Modulates the Hox Code via Polycomb Regulation during Axial Patterning in Vertebrates. eLife. 2020 May 29;9:e53608.
Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H*. Wwp2 maintains cartilage homeostasis through regulation of Adamts5. Nat Commun. 2019 Jun 3;10(1):2429.
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