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Publication List

  1. Washihira N, Murakami M, Nakamura M, Fujii S, Matsushima T, Asahara H, Kishida A, Tanabe T, Kimura T, Kobayashi M, Yamamoto M. Application of a genetically engineered macrophage cell line for evaluating cellular effects of UV/US-treated poly(ethylene terephthalate) microplastics. Colloids Surf B Biointerfaces. 2024 Feb;234:113735. 


  2. Yagasaki L, Chiba T, Kurimoto R, Nakajima M, Iwata T, Asahara H*The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther. 2023 Dec 29;25:186-193.

  3. Inotsume M#, Chiba T#, Matsushima T, Kurimoto R, Nakajima M, Kato T, Shishido K, Liu L, Kawakami K, Asahara H* One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023 Apr;597(7):975-984. Epub 2023 Mar 20.(+VIDEO)

  4. Yamamoto H#, Uchida Y#, Kurimoto R#, Chiba T, Matsushima T, Ito Y, Inotsume M, Miyata K, Watanabe K, Inada M, Goshima N, Uchida T, Asahara H*RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023 Jan;299(1):102791.

  5. Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, Hirose H, Sasahara A, Yano M, Ishikawa S, Inokuchi M, Ota T, Tanabe M, Tada KI, Akiyama T, Cheng X, Liu CC, Yamashita T, Sugano S, Uchida Y, Chiba T, Asahara H, Nakagawa M, Sato S, Miyagi Y, Shimamura T, Nagai LAE, Kanai A, Katoh M, Nomura S, Nakato R, Suzuki Y, Tojo A, Voon DC, Ogawa S, Okamoto K, Foukakis T, Gotoh N. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest. 2023 Nov 15;133(22):e166666023.

  6. Shin J, Miyaki S, Asahara H, Akimoto T. MicroRNA-140 is not involved in sepsis-induced muscle atrophy. Am J Physiol Cell Physiol. 2023 Aug 1;325(2):C509-C518.

  7. Ono Y, Schlesinger S, Fukunaga K, yambe S, Sato T, Sasaki T, Shukunami C, Asahara H, Inui M. Scleraxis-lineage cells are required for correct muscle patterning. Development. 2023 May 15;150(10).


  8. Nakamichi R, Ma S, Nonoyama T, Chiba T, Kurimoto R, Ohzono H, Olmer M, Shukunami C, Fuku N, Wang F, Morrison E, Pitsiladis YP, Ozaki T, D’Lima D, Lotz M, Patapoutian A, Asahara H*. The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Sci Transl Med. 2022 Jun;14(647):eabj5557.

  9. Takada K#, Chiba T#, Miyazaki T, Yagasaki L, Nakamichi R, Iwata T, Moriyama K, Harada H,  Asahara H*. Single cell RNA sequencing reveals critical functions of Mkx in periodontal ligament homeostasis. Frontiers in Cell and Developmental Biology. 2022 Feb 4;10:795441.

  10. Tsutsumi H, Kurimoto R, Chiba T, Nakamichi R, Matsushima T, Fujii Y, Sanada R, Kato T, Shishido K, Sakamaki Y, Kimura T, Kishida A, Asahara H*Generation of a tendon-like tissue from human iPS cells. J Tissue Eng. 2022 Jan 21;13:20417314221074018.

  11. Nakamichi R, Asahara H*Motion-capture Analysis of Mice Using a Video Recorded on an iPhone Camera. Bio Protoc. 2022 12(21): e4539.

  12. Fujii Y, Liu L, Yagasaki L, Inotsume M, Chiba T, Asahara H*. Cartilage Homeostasis and OsteoarthritisInt J Mol Sci. 2022 Jun 5;23(11):6316.

  13. Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal. 2022 Nov;15(758):eabl5304.

  14. Kawata M, Teramura T, Ordoukhanian P, Head SR, Natarajan P, Sundaresan A, Olmer M, Asahara H, Lotz MK. Krüppel-like factors-4 and -2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritisAnnals Rheum Dis. 2022 May 9:annrheumdis-2021-221867.

  15. Sasako T, Umehara T, Soeda K, Kaneko K, Suzuki M, Kobayashi N, Okazaki Y, Tamura-Nakano M, Chiba T, Accili D, Kahn CR, Noda T, Asahara H, Yamauchi T, Kadowaki T, Ueki K. Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice. Nat Commun. 2022 Oct 5;13(1):5655. 


  16. Ito Y, Matsuzaki T, Ayabe F, Mokuda S, Kurimoto R, Matsushima T, Mochizuki Y, Inotsume M, Tsutsumi H, Liu L, Shinohara M, Tanaka Y, Nakamichi R, Nishida K, Lotz M, Asahara H*Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis. Nat Commun.  2021 Jul 6;12(1):4148.

  17. Miyazaki T#, Kurimoto R#, Chiba T, Matsushima T, Nakamichi R, Tsutsumi H, Takada K, Yagasaki L, Kato T, Shishido K, Kobayashi Y, Matsumoto T, Moriyama K*, Asahara H*Mkx regulates the orthodontic tooth movement via osteoclast induction. JBMM. 2021 May 14. 

  18. Uchida Y#, Matsushima T#, Kurimoto R#, Chiba T, Inutani Y, Asahara H*. Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cellsFEBS Letters. 2021 Mar;595(5):563-576. (editor's choice) 

  19. Chiba T, Kurimoto R, Matsuhima T, Ito Y, Nakamichi R, Lotz M, Asahara H*MicroRNA expression profiling, and target identification and validation in chondrocytesMethods in Molecular Biology Book. 2021;2245:151-166. 

  20. Nakamichi R, Asahara H*. Regulation of tendon and ligament differentiation. Bone.  2021 Feb;143:115609.


  21. Yamamoto H#, Uchida Y#, Chiba T#, Kurimoto R, Matsushima T, Ishikawa C, Li H, Shiga T, Muratani M, Uchida T*, Asahara H*Transcriptome analysis of sevoflurane exposure effects at the different brain regions. PloS One. 2020 Dec 15;15(12):e0236771. 

  22. Kurimoto R, Chiba T, Ito Y, Matsushima T, Yano Y, Miyata K, Yashiro Y, Suzuki T, Tomita K, Asahara H*The tRNA pseudouridine synthase TruB1 regulates the maturation and function of let-7 miRNA. EMBO J.   2020 Sep 14:e104708. 

  23. Sato T, Kataoka K, Ito Y, Yokoyama S, Inui M, Mori M, Takahashi S, Akita K, Takada S, Ueno-Kudoh H, Asahara H*. Lin28a/let-7 Pathway Modulates the Hox Code via Polycomb Regulation during Axial Patterning in Vertebrates. eLife. 2020 May 29;9:e53608. 

  24. Kataoka K, Kurimoto R, Tsutsumi H, Chiba T, Kato T, Shishido K, Kato M, Ito Y, Cho Y, Hoshi O, Mimata A, Sakamaki Y, Nakamichi R, Lotz MK, Naruse K*,  Asahara H*. In vitro neo-genesis of tendon-like tissue by combination of Mohawk and a three dimensional cyclic mechanical stretch culture system. Frontiers in Cell and Developmental Biology. 2020 Jun 2;8:307. 

  25. Yano Y, Chiba T, Asahara H*. Analysis of the mouse Y chromosome by single molecule sequencing with Y chromosome enrichment. Frontiers in Genetics. 2020 May 7;11:406. 

  26. Nakamchi R#, Kurimoto R#, Tabata Y#,  Asahara H*Transcriptional, Epigenetic and microRNA regulation of growth plate. Bone. 2020 Aug;137:115434.

  27. Gracey E, Burssens A, Cambre I, Schett G, Lories R, McInnes I, Asahara H, Elewaut D. Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis. Nat Rev Rheumatol. 2020 Apr;16(4):193-207. 

  28. Nakamichi R, Asahara H*. The transcription factors regulating intervertebral disc development. JOR Spine. 2020 Feb 20. ;3(1):e1081.

  29. Mokuda S, Nakamichi R, Ito Y, Asahara H*. Genetic, Epigenetic, and MicroRNA Regulation of Osteoarthritis. 2020. In: Zaidi, M (ed.) Encyclopedia of Bone Biology, vol.[1], pp. 641-651. Oxford: Academic Press. (Book Chapter)

  30. Itano K, Ochiai K, Matsushima T, Asahara H, Takahashi K*. Automation of Foci-Cell-State Judgement with Regression Models. Transactions of the Institute of Systems, Control and Information Engineers. 2021 Volume 34 Issue 3

  31. Lee KI, Gamini R, Olmer M, Ikuta Y, Hasei J, Baek J, Alvarez-Garcia O, Grogan SP, D'Lima DD, Asahara H, Su AI, Lotz MK*. Mohawk is a meniscus transcription factor that promotes meniscus cell phenotype, tissue repair and reduces osteoarthritis severitySci Transl Med. 2020 Oct 28;12(567):eaan7967. 

  32. Isobe M, Toya H, Mito M, Chiba T, Asahara H, Hirose T, Nakagawa S. Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice.​ RNA. 2020 Mar;26(3):251-264.


  33. Yamashita S#, Kataoka K#, Yamamoto H#, Kato T, Hara S, Yamaguchi K, Renard-Guillet C, Katou Y, Shirahige K, Ochi H, Ogino H, Uchida T, Inui M, Takada S, Shigenobu S*, Asahara H*Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken. Sci Rep. 2019 Aug 29;9(1):12560.

  34. Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H*. Wwp2 maintains cartilage homeostasis through regulation of Adamts5Nat Commun. 2019 Jun 3;10(1):2429.

  35. Uchida Y, Chiba T, Kurimoto R, Asahara H*. Post-transcriptional regulation of inflammation by RNA binding proteins via cis-elements of mRNAs. J Biochem. 2019 Nov 1;166(5):375-382. 

  36. Adriaens C, Rambow F, Bervoets G, Silla T, Mito M, Chiba T, Asahara H, Hirose T, Nakagawa S, Heick Jensen T and Marine J, The lncRNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growthRNA. 2019 Dec;25(12):1681-1695.

  37. Sasako T, Ohsugi M, Kubota N, Itoh S, Okazaki Y, Terai A, Kubota T, Yamashita S, Nakatsukasa K, Kamura T, Iwayama K, Tokuyama K, Kiyonari H, Furuta Y, Shibahara J, Fukayama M, Enooku K, Okushin K, Tsutsumi T, Tateishi R, Tobe K, Asahara H, Koike K, Kadowaki T, Ueki K. Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun. 2019 Feb 27;10(1):947

  38. Kita M, Nakae J, Kawano Y, Asahara H, Takemori H, Okado H, Itoh H. Zfp238 regulates the thermogenic program in cooperation with Foxo1. iScience. 2019 Feb 22;12:87-101. 


  39. Mitsumura T#, Ito Y#, Chiba T#, Matsushima T, Kurimoto R, Tanaka Y, Kato T, Uchida K, Ito T, Yamamoto K, Eishi Y, Kitagawa M, Miyazaki Y, Inase N, Asahara H*Ablation of miR-146b in mice causes hematopoietic malignancy. Blood Adv. 2018 Dec 11;2(23):3483-3491.

  40. Mochizuki Y, Chiba T, Kataoka K, Yamashita S, Sato T, Kato T, Takahashi K, Miyamoto T, Kitazawa M, Hatta T, Natsume T, Takai S, Asahara H*Combinatorial CRISPR/Cas9-approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression. Dev Cell. 2018 Sep 24;46(6):794-806.

  41. Inui M#*, Mokuda S#, Sato T, Tamano M, Takada S, Asahara H*Dissecting the roles of miR-140 and its host gene. Nat Cell Biol. (correspondence) 2018 May;20(5):516-518.

  42. Kataoka K#, Matsushima T#, Ito Y, Sato T, Yokoyama S, Asahara H*. Bhlha9 regulates apical ectodermal ridge formation during limb development. JBMM. 2018 Jan;36(1):64-72. 

  43. Nakamichi R, Kataoka K, Asahara H*. Essential role of Mohawk for tenogenic tissues homeostasis including spinal disc and periodontal ligamentMod Rheumatol. 2018 Nov;28(6):933-940.

  44. Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H, Takada S. A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development. Hum Mol Genet. 2018 Sep 15;27(18):3283-3292. 

  45. Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, Lotz MK. FOXO  are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. Aging Cell. 2018 Oct;17(5):e12800. Epub 2018 Jul 2.

  46. Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. Sci Transl Med. 2018 Feb 14;10(428).


  47. Yokoyama S#, Furukawa S#, Kitada S#, Mori M, Saito T, Kawakami K, Izpisua Belmonte JC, Kawakami Y, Ito Y, Sato T, Asahara H*. Analysis of transcription factors expressed at the anterior mouse limb budPLoS One. 2017 May 3;12(5):e0175673. 

  48. Ito Y, Inoue A, Seers T, Hato Y, Igarashi A, Toyama T, Taganov K, Boldin M, Asahara H*Identification of targets of tumor suppressor microRNA-34a using a reporter library system. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3927-3932. 

  49. Hasei J#, Teramura T#, Takehara T, Onodera Y, Horii T, Olmer M, Hatada I, Fukuda K, Ozaki T, Lotz M, Asahara H*TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytesSci Rep. 2017 Feb 21;7:42990. 

  50. Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H*Complementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproductiontranPLoS Genetics. 2017 Jan 23;13(1):e1006578. 

  51. Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H*. The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament. Development.  2017 Jan 15;144(2):313-320

  52. Asahara H*, Inui M*, Lotz M*. Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis.   JBMR.  2017 Sep;32(9):1773-1782. Review.

  53. Miyata K, Naito M, Miyata T, Mokuda S, Asahara H*. Bisulfite Sequencing for DNA Methylation Analysis of Primary Muscle Stem Cells. Methods Mol Biol. 2017;1668:3-13. Review.

  54. Shiba D, Mizuno H, Yumoto A, Shimomura M, Kobayashi H, Morita H, Shimbo M, Hamada M, Kudo T, Shinohara M, Asahara H, Shirakawa M, Takahashi S. Development of new experimental platform 'MARS'-Multiple Artificial-gravity Research System-to elucidate the impacts of micro/partial gravity on mice. Sci Rep. 2017 Sep 7;7(1):10837. 

  55. Okuda K, Kobayashi S, Fukaya M, Watanabe A, Murakami T, Hagiwara M, Sato T, Ueno H, Ogonuki N, Komano-Inoue S, Manabe H, Yamaguchi M, Ogura A, Asahara H, Sakagami H, Mizuguchi M, Manabe T, Tanaka T. CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility. Neurobiol Dis. 2017 Oct;106:158-170. 

  56. Yachie N, Robotic Biology Consortium, Natsume T, Robotic crowd biology with Maholo LabDroidsNat Biotech. (correspondence) 2017 Apr 11;35(4):310-312. 

  57. Matsui-Hasumi A, Sato Y, Uto-Konomi A, Yamashita S, Uehori J, Yoshimura A, Yamashita M, Asahara H, Suzuki S, Kubo M. E3 ubiquitin ligases SIAH1/2 regulates hypoxia-inducible factor 1(HIF1)-mediated TH17 cell differentiation.  Int Immunol. 2017 Mar 1;29(3):133-143.

  58. Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M. Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin. J Neurosci. 2017 Mar 22;37(12):3181-3191. 

  59. Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S. ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. J Hepatol. 2017 May;66(5):942-951.

  60. Saito T, Hara S, Tamano M, Asahara H, Takada S. Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice. J Reprod Dev.  2017 Feb 16;63(1):101-109.  

  61. Otero M, Peng H, El Hachem K, Culley KL, Wondimu EB, Quinn J, Asahara H, Tsuchimochi K, Hashimoto K, Goldring MB. ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by Inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity. Connect Tissue Res. 2017 Jan;58(1):15-26. 


  62. Naito M, Mori M, Inagawa M, Miyata K, Hashimoto N, Tanaka S, Asahara H*Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2. PLoS Genetics. 2016 Jul 14;12(7):e1006167.

  63. Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz M, Sakai D, Masuda K, Ozaki T, Asahara H*Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.   Nat Commun. 2016 Aug 16;7:12503.

  64. Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz M, Okawa A, Asahara H* Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.  Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. 

  65. Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H*Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon. Mol Cell Biol. 2016 Mar 31;36(8):1297-309. 

  66. Chiba T, Ito Y, Asahara H*. Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein. Biomedical Sciences. 2016 2(3): 16-23. Review.

  67. Asahara H*Current Status and Strategy of microRNA Research for Cartilage Development and Osteoarthritis Pathogenesis. J Bone Metab. 2016 Aug;23(3):121-7. Review.

  68. Ito Y, Mokuda S, Miyata K, Matsushima T, Asahara H* MicroRNAs in Chronic Inflammation Diseases Chronic Inflammation (Chapter 6) 2016 Springer Japan. Review. Book. 

  69. Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami K, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TA, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S. Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. Exp Anim. 2016 May 20;65(2):175-87.

  70. Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, Yamashita S, Asahara H, Iida M, Fujii S, Ikura T, Liu Z, Nandu T, Kraus WL, Ueda H, Ito T. SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation. Sci Rep. 2016 Feb 18;6:20179. 


  71. Matsubara Y#, Kato T#, Kashimada K, Tanaka H, Zhi Z, Ichinose S, Mizutani S, Morio T, Chiba T, Ito Y, Saga Y, Takada S*, Asahara H*. TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis. Stem Cells Dev. 2015 May 15;24(10):1164-70. 

  72. Miyata K#, Miyata T#, Nakabayashi K#, Okamura K, Naito M, Kawai T, Takada S, Kato K, Miyamoto S, Hata K, Asahara H*DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation. Hum Mol Genet. 2015 Jan 15;24(2):410-23. 

  73. Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, Inui M, Takada S, Ito Y, Sekiya I, Muneta T, Lotz M, Asahara H*Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J Orthop Res. 2015 Jan;33(1):1-8. 

  74. Gernapudi R, Wolfson B, Zhang Y, Yao Y, Yang P, Asahara H, Zhou Q. MicroRNA 140 Promotes Expression of Long Noncoding RNA NEAT1 in Adipogenesis. Mol Cell Biol. 2015 Oct 12;36(1):30-8.

  75. Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T. Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice. PLoS One. 2015 Oct 29;10(10):e0141650.

  76. Ogura Y, Miyake N, Kou I, Iida A, Nakajima M, Takeda K, Fujibayashi S, Shiina M, Okada E, Toyama Y, Iwanami A, Ishii K, Ogata K, Asahara H, Matsumoto N, Nakamura M, Matsumoto M, Ikegawa S. Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst. PLoS One. 2015 Nov 6;10(11):e0142126.


  77. Matsubara Y#, Chiba T#, Kashimada K, Morio T, Takada S, Mizutani S, Asahara H*Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus. Sci Rep. 2014 May 23;4:5043.

  78. Onizuka N, Ito Y, Inagawa M, Nakahara H, Takada S, Lotz M, Toyama Y, Asahara H*The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates. J Orthop Sci. 2014 Jan;19(1):172-80. Epub 2013 Oct 29.

  79. Nagata E, Kano H, Kato F, Yamaguchi R, Nakashima S, Takayama S, Kosaki R, Tonoki H, Mizuno S, Watanabe S, Yoshiura K, Kosho T, Hasegawa T, Kimizuka M, Suzuki A, Shimizu K, Ohashi H, Haga N, Numabe H, Horii E, Nagai T, Yoshihashi H, Nishimura G, Toda T, Takada S, Yokoyama S, Asahara H, Sano S, Fukami M, Ikegawa S, Ogata T. Japanese founder duplications/triplications involving BHLHA9 are associated with split-hand/foot malformation with or without long bone deficiency and Gollop-Wolfgang complex. Orphanet J Rare Dis. 2014 Oct 21;9:125.

  80. Miyata K, Yotsumoto F, Nam SO, Odawara T, Manabe S, Ishikawa T, Itamochi H, Kigawa J, Takada S, Asahara H, Kuroki M, Miyamoto S. Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma. Cancer Med. 2014 Oct;3(5):1159-69. 

  81. Inui M, Miyado M, Igarashi M, Tamano M, Kubo A, Yamashita S, Asahara H, Fukami M, Takada S. Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system. Sci Rep. 2014 Jun 23;4:5396.

  82. Takasawa K, Kashimada K, Pelosi E, Takagi M, Morio T, Asahara H, Schlessinger D, Mizutani S, Koopman P. FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J. 2014 May;28(5):2020-8. 

  83. Shinohara M, Chang BY, Buggy JJ, Nagai Y, Kodama T, Asahara H, Takayanagi H. The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss. Bone. 2014 Mar;60:8-15. 

  84. Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, Lotz MK. Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis. Osteoarthritis Cartilage. 2014 Jan;22(1):162-70.  


  85. Yoshitaka T, Kawai A, Miyaki S, Numoto K, Kikuta K, Ozaki T, Lotz M, Asahara H*Analysis of microRNAs expressions in chondrosarcoma. J Orthop Res. 2013 Dec;31(12):1992-8. 

  86. Kato T#, Miyata K#, Sonobe M, Yamashita S, Tamano M, Miura K, Kanai Y, Miyamoto S, Sakuma T, Yamamoto T, Inui M, Kikusui T, Asahara H*, Takada S*Production of Sry knockout mouse using TALEN via oocyte injection. Sci Rep. 2013 Nov 5;3:3136.

  87. Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, Ozaki T, Lotz MK, Asahara H*Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Arthritis Rheum. 2013 Aug;65(8):2081-9.

  88. Shimizu H#, Kubo A#, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H*The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013 Oct 16;8(10):e75754.

  89. Takada S, Sato T, Ito Y, Yamashita S, Kato T, Kawasumi M, Kanai-Azuma M, Igarashi A, Kato T, Tamano M, Asahara H*Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One. 2013 Oct 16;8(10):e76004.

  90. Watanabe T, Oyama T, Asada M, Harada D, Ito Y, Inagawa M, Suzuki Y, Sugano S, Katsube K, Karsenty G, Komori T, Kitagawa M, Asahara H*MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genetics. 2013;9(1):e1003132. 

  91. Gibson G*, Asahara H*microRNAs and cartilage. J Orthop Res. 2013 Sep;31(9):1333-44. Review.

  92. Furumatsu T*, Asahara H*. Chromatin assembly and in vitro transcription analyses for evaluation of individual protein activities in multicomponent transcriptional complexes. Methods Mol Biol. 2013;977:193-202. Review.

  93. Rakoczy J, Fernandez-Valverde SL, Glazov EA, Wainwright EN, Sato T, Takada S, Combes AN, Korbie DJ, Miller D, Grimmond SM, Little MH, Asahara H, Mattick JS, Taft RJ, Wilhelm D. MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biol Reprod. 2013 Jun 6;88(6):143.

  94. Hasegawa A, Nakahara H, Kinoshita M, Asahara H, Koziol J, Lotz MK. Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis. Arthritis Res Ther. 2013 Feb 14;15(1):R29.

  95. Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK, Asahara H, Ishiguro N. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Res Ther. 2013 Feb 13;15(1):R28.

  96. Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Hikiba Y, Obi S, Goto T, Kang YJ, Maeda S, Yoshida H, Omata M, Asahara H, Koike K. MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression. Hepatology. 2013 Jan;57(1):162-70.  


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