2025

1. Tsutsumi H, Chiba T, Fujii Y, Matsushima T, Kimura T, Kanai A, Kishida A, Suzuki Y, Asahara H*. Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells. eLife.  2025 14:RP104768

2. Liu L, Chiba T, Matsushima T, Inotsume M, Kato T, Hiraoka Y, Asahara H*. Gene dosage-dependent roles of Mkx in postnatal tendon development and maintenance revealed by conditional deletion.  Dev Biol.  2025 Jun 21:526:15-25.

3. Matsushima T, Naito Y, Chiba T, Kurimoto R, Itano I, Ochiai K, Takahashi K, Goshima N, Asahara H*. Localizatome: a database for stress-dependent subcellular localization changes in proteins.  Database (Oxford).  2025 Apr 21:2025:baaf028.

4. Chida S, Chiba T, Uchida Y, Matsushima T, Kurimoto R, Miyazaki T, Yagasaki L, Nakamura S, Mihara E, Takagi J, Moriyama K, Asahara H*. Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement. J Bone Miner Metab. 2025 May;43(3):216-229.
   --------------Review     

5. Asahara H*. Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system. Proc Jpn Acad Ser B Phys Biol Sci.  2025;101(7):373-393.
   --------------------------Collaboration​

6. Ito J, Miyake K, Chiba T, Takahashi K, Uchida Y, Blackshear PJ, Asahara H, Karasuyama H. Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses. Allergol Int. 2025 Apr;74(2):263-273. ​

7. Xie Y, Huang Y, Chettiar V, Xing T, Huang SK, Moore BB, Asahara H, Abel PW, Tu Y. miR-146b disrupts the epidermal growth factor receptor/transforming growth factor β receptor profibrotic feedforward loop to inhibit lung fibroblast proliferation and differentiation. J Pharmacol Exp Ther. 2025 Sep;392(9):103672. 

8. Tsuchiya Y, Matsuo H, Asahara H, Inui M. Matrix stiffness regulates Mkx expression in rat tenocyte through TRPM7. Biochemistry and Biophysics Reports. 2025 Jul 23:43:102178. 

9. Goto A, Komura S, Kato K, Maki R, Hirakawa A, Aoki H, Tomita H, Taguchi J, Ozawa M, Matsushima T, Kishida A, Kimura T, Asahara H, Imai Y, Yamada Y, Akiyama H. PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration. Nat Commun . 2025 Apr 20;16(1):3734.

10. Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med.  2025 Mar 3;222(3):e20230647. 
    
    2024     

11. Uchida Y, Kurimoto R, ChibaT, Matsushima T, Oda G, Onishi I, Takeuchi Y, Gotoh N,  Asahara H*. RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer. EMBO Rep. 2024 Dec;25(12):5352-5382. 
    --------------Review     

12. Nakamichi R, Asahara H*. The role of mechanotransduction in tendon. J Bone Miner Res. 2024 Aug 5;39(7):814-820.

13. Matsushima T, Asahara H*. Molecular mechanisms of mechanosensing and plasticity of tendons and ligaments. J Biochem. 2024 May 10:mvae039. 
    --------------------------Collaboration

14. Washihira N, Murakami M, Nakamura M, Fujii S, Matsushima T, Asahara H, Kishida A, Tanabe T, Kimura T, Kobayashi M, Yamamoto M. Application of a genetically engineered macrophage cell line for evaluating cellular effects of UV/US-treated poly(ethylene terephthalate) microplastics. Colloids Surf B Biointerfaces. 2024 Feb;234:113735. 
    
    2023    

15. Yagasaki L, Chiba T, Kurimoto R, Nakajima M, Iwata T, Asahara H*. The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum. Regen Ther. 2023 Dec 29;25:186-193.

16. Inotsume M#, Chiba T#, Matsushima T, Kurimoto R, Nakajima M, Kato T, Shishido K, Liu L, Kawakami K, Asahara H*.  One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023 Apr;597(7):975-984. Epub 2023 Mar 20.(+VIDEO)

17. Yamamoto H#, Uchida Y#, Kurimoto R#, Chiba T, Matsushima T, Ito Y, Inotsume M, Miyata K, Watanabe K, Inada M, Goshima N, Uchida T, Asahara H*. RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023 Jan;299(1):102791.
    --------------------------Collaboration

18. Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, Hirose H, Sasahara A, Yano M, Ishikawa S, Inokuchi M, Ota T, Tanabe M, Tada KI, Akiyama T, Cheng X, Liu CC, Yamashita T, Sugano S, Uchida Y, Chiba T, Asahara H, Nakagawa M, Sato S, Miyagi Y, Shimamura T, Nagai LAE, Kanai A, Katoh M, Nomura S, Nakato R, Suzuki Y, Tojo A, Voon DC, Ogawa S, Okamoto K, Foukakis T, Gotoh N. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest. 2023 Nov 15;133(22):e166666023.

19. Shin J, Miyaki S, Asahara H, Akimoto T. MicroRNA-140 is not involved in sepsis-induced muscle atrophy. Am J Physiol Cell Physiol. 2023 Aug 1;325(2):C509-C518.

20. Ono Y, Schlesinger S, Fukunaga K, yambe S, Sato T, Sasaki T, Shukunami C, Asahara H, Inui M. Scleraxis-lineage cells are required for correct muscle patterning. Development. 2023 May 15;150(10).
    
    2022

21. Nakamichi R, Ma S, Nonoyama T, Chiba T, Kurimoto R, Ohzono H, Olmer M, Shukunami C, Fuku N, Wang F, Morrison E, Pitsiladis YP, Ozaki T, D’Lima D, Lotz M, Patapoutian A, Asahara H*. The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Sci Transl Med. 2022 Jun;14(647):eabj5557.

22. Takada K#, Chiba T#, Miyazaki T, Yagasaki L, Nakamichi R, Iwata T, Moriyama K, Harada H,  Asahara H*. Single cell RNA sequencing reveals critical functions of Mkx in periodontal ligament homeostasis. Frontiers in Cell and Developmental Biology. 2022 Feb 4;10:795441.

23. Tsutsumi H, Kurimoto R, Chiba T, Nakamichi R, Matsushima T, Fujii Y, Sanada R, Kato T, Shishido K, Sakamaki Y, Kimura T, Kishida A, Asahara H*. Generation of a tendon-like tissue from human iPS cells. J Tissue Eng. 2022 Jan 21;13:20417314221074018.

24. Nakamichi R, Asahara H*. Motion-capture Analysis of Mice Using a Video Recorded on an iPhone Camera. Bio Protoc. 2022 12(21): e4539.
    --------------Review

25. Fujii Y, Liu L, Yagasaki L, Inotsume M, Chiba T, Asahara H*. Cartilage Homeostasis and Osteoarthritis. Int J Mol Sci. 2022 Jun 5;23(11):6316.
    --------------------------Collaboration

26. Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal. 2022 Nov;15(758):eabl5304.

27. Kawata M, Teramura T, Ordoukhanian P, Head SR, Natarajan P, Sundaresan A, Olmer M, Asahara H, Lotz MK. Krüppel-like factors-4 and -2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis. Annals Rheum Dis. 2022 May 9:annrheumdis-2021-221867.

28. Sasako T, Umehara T, Soeda K, Kaneko K, Suzuki M, Kobayashi N, Okazaki Y, Tamura-Nakano M, Chiba T, Accili D, Kahn CR, Noda T, Asahara H, Yamauchi T, Kadowaki T, Ueki K. Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice. Nat Commun. 2022 Oct 5;13(1):5655. 
    
    2021    

29. Ito Y, Matsuzaki T, Ayabe F, Mokuda S, Kurimoto R, Matsushima T, Mochizuki Y, Inotsume M, Tsutsumi H, Liu L, Shinohara M, Tanaka Y, Nakamichi R, Nishida K, Lotz M, Asahara H*. Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis. Nat Commun.  2021 Jul 6;12(1):4148.

30. Miyazaki T#, Kurimoto R#, Chiba T, Matsushima T, Nakamichi R, Tsutsumi H, Takada K, Yagasaki L, Kato T, Shishido K, Kobayashi Y, Matsumoto T, Moriyama K*, Asahara H*. Mkx regulates the orthodontic tooth movement via osteoclast induction. JBMM. 2021 May 14. 

31. Uchida Y#, Matsushima T#, Kurimoto R#, Chiba T, Inutani Y, Asahara H*. Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells. FEBS Letters. 2021 Mar;595(5):563-576. (editor's choice) 
    --------------Review

32. Chiba T, Kurimoto R, Matsuhima T, Ito Y, Nakamichi R, Lotz M, Asahara H*. MicroRNA expression profiling, and target identification and validation in chondrocytes. Methods in Molecular Biology Book. 2021;2245:151-166. 

33. Nakamichi R, Asahara H*. Regulation of tendon and ligament differentiation. Bone.  2021 Feb;143:115609.
    
     
    
    
    Top