Publication List

         2008-1995

    2008

  1. Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, Asahara H*Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum. 2008 May;58(5):1284-92.

  2. Yokoyama S, Hashimoto M, Shimizu H, Ueno-Kudoh H, Uchibe K, Kimura I, Asahara H*Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken. Gene Expr Patterns. 2008 Feb;8(3):155-60. 
    --------------Review

  3. Hashimoto M, Nakasa T, Hikata T, Asahara H*Molecular  network of cartilage homeostasis and osteoarthritis. Med Res Rev. 2008 May;28(3):464-81. Review.

  4. Yoshitaka T,  Asahara H*. Epigenetics and Cartilage Regulation. US Musculoskeletal Review. 2008; 3(1): 45-47. Review.
    ---------------------------Collaboration

  5. Sakai N, Terami H, Suzuki S, Haga M, Nomoto K, Tsuchida N, Morohashi K, Saito N, Asada M, Hashimoto M, Harada D, Asahara H, Ishikawa T, Shimada F, Sakurada K. Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. J Endocrinol. 2008 Sep;198(3):489-97. 

    2007

  6. Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H*Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol. 2007 Aug;27(16):5650-63. 
    --------------Review

  7. Shimizu H, Yokoyama S, Asahara H*Growth and differentiation of the developing limb bud from the perspective of chondrogenesis. Dev Growth Differ. 2007 Aug;49(6):449-54. Review. 

    2006

  8. Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006 Dec;12(12):1410-6. E 

    2005

  9. Furumatsu T, Tsuda M, Yoshida K, Taniguchi N, Ito T, Hashimoto M, Ito T, Asahara H*Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem. 2005 Oct 21;280(42):35203-8. 

  10. Furumatsu T, Tsuda M, Taniguchi N, Tajima Y, Asahara H*Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. J Biol Chem. 2005 Mar 4;280(9):8343-50. 

  11. Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban CR, Zemmyo M, Furumatsu T, Lotz M, Izpisúa Belmonte JC, Asahara H*Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2414-9.  

    2004

  12. Nishida K, Komiyama T, Miyazawa S, Shen ZN, Furumatsu T, Doi H, Yoshida A, Yamana J, Yamamura M, Ninomiya Y, Inoue H, Asahara HHistone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) expression. Arthritis Rheum. 2004 Oct;50(10):3365-76.
    ---------------------------Collaboration

  13. Omoto S, Nishida K, Yamaai Y, Shibahara M, Nishida T, Doi T, Asahara H, Nakanishi T, Inoue H, Takigawa M. Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. Osteoarthritis Cartilage. 2004 Oct;12(10):771-8.

  14. Kato T, Asahara H, Kurokawa MS, Fujisawa K, Hasunuma T, Inoue H, Tsuda M, Takahashi S, Motokawa S, Sumida T, Nishioka K. HTLV-I env protein acts as a major antigen in patients with HTLV-I-associated arthropathy. Clin Rheumatol. 2004 Oct;23(5):400-9. 

    2003

  15. Tsuda M, Takahashi S, Takahashi Y, Asahara H*Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9. J Biol Chem. 2003 Jul 18;278(29):27224-9. 
    ---------------------------Collaboration

  16. Kawakami Y, Rodríguez-León J, Koth CM, Büscher D, Itoh T, Raya A, Ng JK, Esteban CR, Takahashi S, Henrique D, Schwarz MF, Asahara H, Izpisúa Belmonte JC. MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat Cell Biol. 2003 Jun;5(6):513-9.

  17. Canettieri G, Morantte I, Guzmán E, Asahara H, Herzig S, Anderson SD, Yates JR 3rd, Montminy M. Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat Struct Biol. 2003 Mar;10(3):175-81. 

    2002

  18. Asahara H, Tartare-Deckert S, Nakagawa T, Ikehara T, Hirose F, Hunter T, Ito T, Montminy M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol Cell Biol. 2002 May;22(9):2974-83. 

    2001

  19. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson BM, Montminy M, Evans RM. A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21;294(5551):2507-11. 

  20. Asahara H, Santoso B, Guzman E, Du K, Cole PA, Davidson I, Montminy M. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Mol Cell Biol. 2001 Dec;21(23):7892-900.

  21. Long F, Schipani E, Asahara H, Kronenberg H, Montminy M. The CREB family of activators is required for endochondral bone development. Development. 2001 Feb;128(4):541-50.

  22. Sekine T, Masuko-Hongo K, Matsui T, Asahara H, Takigawa M, Nishioka K, Kato T. Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis. Ann Rheum Dis. 2001 Jan;60(1):49-54. 

    2000

  23. Du K, Asahara H, Jhala US, Wagner BL, Montminy M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol Cell Biol. 2000 Jun;20(12):4320-7.

  24. Asaumi K, Nakanishi T, Asahara H, Inoue H, Takigawa M. Expression of neurotrophins and their receptors (TRK) during fracture healing. Bone. 2000 Jun;26(6):625-33.

  25. Shibahara M, Nishida K, Asahara H, Yoshikawa T, Mitani S, Kondo Y, Inoue H. Increased osteocyte apoptosis during the development of femoral head osteonecrosis in spontaneously hypertensive rats. Acta Med Okayama. 2000 Apr;54(2):67-74.

  26. Michael LF, Asahara H, Shulman AI, Kraus WL, Montminy M. The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism. Mol Cell Biol. 2000 Mar;20(5):1596-603. 

    1999

  27. Asahara H, Dutta S, Kao HY, Evans RM, Montminy M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol. 1999 Dec;19(12):8219-25.

  28. Suzuki M, Asahara H, Endo S, Inada K, Doi M, Kuroda K, Ogawa A. Increased levels of nitrite/nitrate in the cerebrospinal fluid of patients with subarachnoid hemorrhage. Neurosurg Rev. 1999 Oct;22(2-3):96-8.

  29. Maeda T, Keino H, Asahara H, Taniguchi M, Nishioka K, Sumida T. Decreased TCR AV24AJ18+ double-negative T cells in rheumatoid synovium. Rheumatology (Oxford). 1999 Feb;38(2):186-8. 

    1998

  30. Okamoto K, Asahara H, Kobayashi T, Matsuno H, Hasunuma T, Kobata T, Sumida T, Nishioka K. Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Ther. 1998 Mar;5(3):331-8.

  31. Takagoshi H, Hashizume H, Nishida K, Masaoka S, Asahara H, Inoue H. Fibrous structure and connection surrounding the metacarpophalangeal joint. Acta Med Okayama. 1998 Feb;52(1):19-26.

  32. Pu J, Nishida K, Inoue H, Asahara H, Ohtsuka A, Murakami T. Mast cells in osteoarthritic and rheumatoid arthritic synovial tissues of the human knee. Acta Med Okayama. 1998 Feb;52(1):35-9.

  33. Sumida T, Hasunuma T, Asahara H, Maeda T, Nishioka K. Rheumatoid arthritis and apoptosis. Intern Med. 1998 Feb;37(2):184-8. Review.

  34. Fujisawa K, Okamoto K, Asahara H, Hasunuma T, Kobata T, Kato T, Sumida T, Nishioka K. Evidence for autoantigens of Env/Tax proteins in human T cell leukemia virus type I Env-pX transgenic mice. Arthritis Rheum. 1998 Jan;41(1):101-9. 

    1997

  35. Kobata T, Takasaki K, Asahara H, Hong NM, Masuko-Hongo K, Kato T, Hirose S, Shirai T, Kayagaki N, Yagita H, Okumura K, Nishioka K. Apoptosis with FasL+ cell infiltration in the periphery and thymus of corrected autoimmune mice. Immunology. 1997 Oct;92(2):206-13. 

  36. Xue C, Hasunuma T, Asahara H, Yin W, Maeda T, Fujisawa K, Dong Y, Sumida T, Nishioka K. Transcriptional regulation of the HOX4C gene by basic fibroblast growth factor on rheumatoid synovial fibroblasts. Arthritis Rheum. 1997 Sep;40(9):1628-35.

  37. Asahara H, Fujisawa K, Kobata T, Hasunuma T, Maeda T, Asanuma M, Ogawa N, Inoue H, Sumida T, Nishioka K. Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium. Arthritis Rheum. 1997 May;40(5):912-8.

  38. Suzuki M, Ogawa A, Asahara H, Endo S, Inada K. Nitric oxide and vasospasm. J Neurosurg. 1997 Apr;86(4):741-2.

  39. Asahara H, Hasunuma T, Kobata T, Inoue H, Muller-Ladner U, Gay S, Sumida T, Nishioka K. In situ expression of protooncogenes and Fas/Fas ligand in rheumatoid arthritis synovium. J Rheumatol. 1997 Mar;24(3):430-5.

  40. Sumida T, Hoa TT, Asahara H, Hasunuma T, Nishioka K. T cell receptor of Fas-sensitive T cells in rheumatoid synovium. J Immunol. 1997 Feb 15;158(4):1965-70.

  41. Hasunuma T, Kayagaki N, Asahara H, Motokawa S, Kobata T, Yagita H, Aono H, Sumida T, Okumura K, Nishioka K. Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis. Arthritis Rheum. 1997 Jan;40(1):80-6.

  42. Yokoi I, Kabuto H, Habu H, Inada K, Toma J, Asahara H, Mori A. Structure-activity relationships of guanidine compounds on brain nitric oxide synthase activity. Guanidino Compounds: 2, eds. By P.P. De Deyn, B. Marescau, I.A. Qureshi, A. Mori. John Libbey & Company Ltd. 1997: 3-7. Review. Book.

  43. Habu H, Yokoi I, Kabuto H, Asahara H, Toma J, Inada K, Mori A. The role of nitric oxide on α-guanidinoglutaric acid induced epileptic discharges. Guanidino Compounds: 2, eds. By P.P. De Deyn, B. Marescau, I. A. Qureshi, A. Mori. John Libbey & Company Ltd. 1997: 373-377. Review. Book.

    1996

  44. Hasunuma T, Hoa TT, Aono H, Asahara H, Yonehara S, Yamamoto K, Sumida T, Gay S, Nishioka K. Induction of Fas-dependent apoptosis in synovial infiltrating cells in rheumatoid arthritis. Int Immunol. 1996 Oct;8(10):1595-602.

  45. Asahara H, Hasumuna T, Kobata T, Yagita H, Okumura K, Inoue H, Gay S, Sumida T, Nishioka K. Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue. Clin Immunol Immunopathol. 1996 Oct;81(1):27-34.

  46. Fujisawa K, Asahara H, Okamoto K, Aono H, Hasunuma T, Kobata T, Iwakura Y, Yonehara S, Sumida T, Nishioka K. Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice. J Clin Invest. 1996 Jul 15;98(2):271-8.

  47. Asahara H, Kawai A, Harada Y, Senda M, Inoue H. Spinal schwannomas: a review of 42 cases. Acta Med Okayama. 1996 Feb;50(1):25-8.

  48. Hashizume H, Asahara H, Nishida K, Inoue H, Konishiike T. Histopathology of Kienböck's disease. Correlation with magnetic resonance and other imaging techniques. J Hand Surg Br. 1996 Feb;21(1):89-93.

  49. Asahara H, Yokoi I, Tamada T, Kabuto H, Ogawab N, Mori A, Inoue H. Increased cerebrospinal fluid nitrite and nitrate levels in patients with lumbar spondylosis. Res Commun Mol Pathol Pharmacol. 1996 Jan;91(1):77-83. 

    1995

  50. Asahara H, Asanuma M, Ogawa N, Nishibayashi S, Inoue H. High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis. Biochem Mol Biol Int. 1995 Nov;37(5):827-32.

  51. Asahara H, Kabuto H, Yokoi I, Habu H, Mori A, Inoue H. Nitric oxide synthase inhibited by audouine  in the rat brain. Neuroreport. 1995 May 30;6(8):1146-8.

  52. Kabuto H, Yokoi I, Habu H, Asahara H, Mori A. Inhibitory effect of arcaine on nitric oxide synthase in the rat brain. Neuroreport. 1995 Feb 15;6(3):554-6. 

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