【演者】James Sharpe先生（Head of EMBL Barcelona）【演題】Putting it all together: Building a 4D multiscale model of limb development

第56回システム発生・再生医学分野セミナー ハイブリッド形式にて開催しました

日時：令和8年3月23日（月）10:00-11:00 要旨：Limb development is a paradigm model system for understanding organogenesis. The rapid development of cutting-edge technologies over the past decade for omics and imaging provides us with a huge amount of data. But a true understanding of complex biological systems, will require mathematical models which seek not just to represent and predict, but also to understand the underlying dynamical behaviours over time - in other words to explore mechanistic hypotheses. I will explain some of our work both describing and explaining limb development through computer modelling. In particular, we aim, ultimately, to go beyond the individual mechanistic models of sub-parts of the problem (regionalisation, symmetry-breaking, shape control) and to integrate these into a more complete multi-scale model to understand how these basic modules interact and feedback on each other to create the overall layout (or “bauplan”) of the vertebrate limb.